The Protein Resistin Linked to Increased LDL Cholesterol

by Colin Carmichael

Researchers in Canada have discovered a link between the protein resistin and an increased production in LDL cholesterol.

Of course, LDL cholesterol is known as the "bad" cholesterol and elevated levels are linked to an increased risk of heart disease. But the bad news about resistin goes beyond this study in Canada. That's because resistin has been shown to degrade the LDL receptors in the liver, making it more difficult for the liver to properly handle excess levels of low-density lipoprotein.

So when you've got both excess production and an inability to handle it properly, it's that much easier and more likely for excess cholesterol to accumulate in your arteries. Not good.

This is probably a key reason why resistin is such a strong biomarker for heart failure. Some research now shows it may be just as strong an indicator of heart disease as C-reactive protein (CRP).

Resistin and Statins

The role of resistin is catching the eye of pharmaceutical companies because having elevated levels of resistin has been shown to negatively impact the effectiveness of cholesterol-lowering statin drugs.

It's estimated that as many as 40% of statin users are resistant to the beneficial effects of these drugs. It's believed that excess resistin levels could be the main reason for the lack of effectiveness in these patients.

What's Next?

I'd be willing to bet a crisp $100 bill that the next move from the pharmaceutical companies will be to create a drug that targets resistin.

The result?

If those earlier estimates are correct, 40% or more of all high cholesterol patients will be on two drugs … one to lower cholesterol, and one to lower resistin. (Or possibly a combination drug targeting both of these in one pill.)

The result is the same … more medication for patients, more profits for the drug companies.

Here's a thought…

Why not just avoid this cycle completely and discover how to lower cholesterol without using any harmful drugs or medications?

Resistin and Diabetes

Elevated levels of resistin in the blood has long been associated with being overweight and specifically in patients with diabetes and insulin resistance.

Instead of creating drugs to target and lower resistin artificially, why not do more to educate the public on avoiding high glycemic foods and the role of diet and exercise to avoid the onset of Type II diabetes?

I know, I know. There's not a billion dollars of revenue to be made from that course of action.

Contrary to popular belief, it's not that hard to regulate and lower both your cholesterol and resistin levels naturally with the right dietary choices if you just know the facts. Our daily email tips (below) is a great place to start…


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